Automatic Glucose Control During Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach

Keeping the blood glucose levels within safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also Artificial Pancreas (AP) systems. One of reasons fully (autonomous) closed-loop solution has been released onto market yet is slow action current insulin analogs. To partially overcome this limitation, authors have previously designed switched control strategy equipped an insulin-on-board (IOB) safety loop that mitigates meal-related excursions without carbohydrate counting. In letter, similar based on Linear Parameter-Varying (LPV) law adapted to safely handle challenges minimum user intervention. silico results using UVA/Padova simulator evidence proposed scheme feasible under moderate-intense bouts by effectively reducing risk hypoglycemia.